دانشگاه شهید باهنر کرمان

 آمار

تعداد نشریات26
تعداد شماره‌ها447
تعداد مقالات4,557
تعداد مشاهده مقاله5,380,005
تعداد دریافت فایل اصل مقاله3,580,079
Soltani, Ahad, Babaei, Homayoon, Kheirandish, Reza, Imani, Masoud, Mohammadi, Pourya. (1404). The Effects of Epigallocatechin-3-Gallate Extract Encapsulated by Bio-Polymeric Alginate-Chitosan Nanoparticles on Testicular Histopathology and Histomorphometry of Mice Following LPS-Induced Acute Endotoxemia. , 2(1), 51-59. doi: 10.22103/vcbr.2025.24696.1041
Ahad Soltani; Homayoon Babaei; Reza Kheirandish; Masoud Imani; Pourya Mohammadi. "The Effects of Epigallocatechin-3-Gallate Extract Encapsulated by Bio-Polymeric Alginate-Chitosan Nanoparticles on Testicular Histopathology and Histomorphometry of Mice Following LPS-Induced Acute Endotoxemia". , 2, 1, 1404, 51-59. doi: 10.22103/vcbr.2025.24696.1041
Soltani, Ahad, Babaei, Homayoon, Kheirandish, Reza, Imani, Masoud, Mohammadi, Pourya. (1404). 'The Effects of Epigallocatechin-3-Gallate Extract Encapsulated by Bio-Polymeric Alginate-Chitosan Nanoparticles on Testicular Histopathology and Histomorphometry of Mice Following LPS-Induced Acute Endotoxemia', , 2(1), pp. 51-59. doi: 10.22103/vcbr.2025.24696.1041
Soltani, Ahad, Babaei, Homayoon, Kheirandish, Reza, Imani, Masoud, Mohammadi, Pourya. The Effects of Epigallocatechin-3-Gallate Extract Encapsulated by Bio-Polymeric Alginate-Chitosan Nanoparticles on Testicular Histopathology and Histomorphometry of Mice Following LPS-Induced Acute Endotoxemia. , 1404; 2(1): 51-59. doi: 10.22103/vcbr.2025.24696.1041

The Effects of Epigallocatechin-3-Gallate Extract Encapsulated by Bio-Polymeric Alginate-Chitosan Nanoparticles on Testicular Histopathology and Histomorphometry of Mice Following LPS-Induced Acute Endotoxemia

Veterinary and Comparative Biomedical Research
مقاله 8، دوره 2، شماره 1، شهریور 2025، صفحه 51-59    اصل مقاله (906.89 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22103/vcbr.2025.24696.1041
نویسندگان
Ahad Soltani1؛ Homayoon Babaei* 1؛ Reza Kheirandish2؛ Masoud Imani1؛ Pourya Mohammadi3
1Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
2Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
3Department of Chemistry, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
چکیده
Endotoxemia is a significant cause of mortality and abnormalities in animals, particularly neonates, within the first 24 hours of life. It is triggered by the release of lipopolysaccharide from the cell wall of gram-negative bacteria into the bloodstream. This study aimed to investigate the impact of epigallocatechin gallate (EGCG) in its simple form and as nanoparticles on the histopathological changes in the testes of NMRI mice induced by endotoxemia. Sixteen male mice were divided into four experimental groups. The control group received no treatment, while the other three groups were induced with acute endotoxemia by intraperitoneal injection of 6750 µg/kg of lipopolysaccharide. Group 3 received EGCG treatment (25 mg/kg) and group 4 received nano-EGCG treatment (25 mg/kg) intra-peritoneally once daily for 28 days. Evaluation of testicular tissue parameters, including spermatogenesis percentage, Johnsen's score, and meiotic index, showed improvement in the EGCG-treated groups, with no significant difference between the simple and nano forms. In conclusion, EGCG administration alleviates the adverse effects of acute endotoxemia on testicular tissue, with no significant difference observed between encapsulated and unencapsulated EGCG.
کلیدواژه‌ها
Epigallocatechin gallate؛ Endotoxemia؛ Testes؛ Mice
آمار
تعداد مشاهده مقاله: 65
تعداد دریافت فایل اصل مقاله: 75


سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب