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Effects of Vitamin D3 Supplementation during Mating or Gestation on Antioxidant Status and Reproductive Parameters in Gray Shirazi Ewes | ||
| Veterinary and Comparative Biomedical Research | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 13 مرداد 1404 اصل مقاله (839.29 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22103/vcbr.2025.25380.1074 | ||
| نویسندگان | ||
| Seyed Ehsan Sadat Madani1؛ Meysam Makki* 1؛ Seyedeh Misagh Jalali1؛ Alidad Boostani2؛ Saad Goorani Nejad1 | ||
| 1Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran | ||
| 2Animal Science Research Department, Fars Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Shiraz, Iran | ||
| چکیده | ||
| Recent studies suggest that vitamin D3 may have preventive and therapeutic effects on autoimmune disease, cancer, and type 1 and 2 diabetes beyond the skeletal condition and calcium metabolism. To demonstrate the effects of a single 10,000 IU/kg vitamin D3 IM injection during mating and pregnancy on reproductive and antioxidant factors, 21 Gray Shirazi ewes with a parity of 1 to 3, which were kept under industrial conditions, were used for this research. All ewes underwent estrus synchronization by placing a sponge containing Flurogestone acetate for 13 days, followed by an injection of 400 units of Pregnant Mare Serum Gonadotropin hormone on the 13th day. Then, ewes were divided into three groups: the first group served as control (without any supplementation), the second group, called pre-pregnancy, received vitamin D3 10 days before laparoscopic insemination, and the third group, which received the supplement in mid-pregnancy (at the 15th week of pregnancy). Blood samples were collected from the ewes at four different stages: the first stage was 10 days after vitamin D3 injection (at the time of insemination), the second stage occurred about 15 weeks after insemination (about 10 days after vitamin D3 injection), the third stage was 2 weeks before lambing, and the fourth stage took place 2 weeks after lambing. The study's findings indicated that vitamin D3 supplementation has no significant effect on reproductive factors in Gray Shirazi ewes (p≥0.05). However, a significant decrease in blood cortisol levels was observed during both pre-pregnancy and mid-pregnancy. Additionally, there was a significant increase in antioxidant factors, such as superoxide dismutase and glutathione peroxidase, during mid-pregnancy. This conclusion can be related to the racial differences in sheep, the supplement's dose, and the timing and frequency of injections. | ||
| کلیدواژه‌ها | ||
| Vitamin D3؛ Gray Shirazi Ewes؛ Reproductive Parameters؛ Gestation؛ Antioxidant Status | ||
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آمار تعداد مشاهده مقاله: 1 تعداد دریافت فایل اصل مقاله: 4 |
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