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Comparative Analysis of Oxidative Stress Induced by Chemical and Surgical Castration in Male Dogs | ||
| Veterinary and Comparative Biomedical Research | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 21 مرداد 1404 اصل مقاله (834.8 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22103/vcbr.2025.25128.1062 | ||
| نویسندگان | ||
| Dorrin Azari Motlagh1؛ Reza Asadpour1؛ Seyed Hossein Jarolmasjed1؛ Mohammad Hassan Khadem Ansari2؛ Siamak Kazemi Darabadi* 1 | ||
| 1Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran | ||
| 2Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran | ||
| چکیده | ||
| This study was conducted to investigate the effects of chemical and surgical castration on oxidative stress in male dogs. A total of ten healthy male dogs, aged between 1 and 3 years, were assigned to two distinct groups: Group Surg underwent surgical castration, while Group Chem received chemical castration utilizing zinc gluconate. Blood samples were collected at baseline, as well as at 1 day, 1 week, and 2 weeks following the castration procedures, in order to measure indicators of oxidative stress. The parameters assessed included total antioxidant capacity, superoxide dismutase, and malondialdehyde activities. The results indicated an increase in malondialdehyde levels immediately following both procedures, suggesting an elevation in oxidative stress. Conversely, superoxide dismutase levels exhibited a significant increase in the Surg group, indicating a robust antioxidant response. Total antioxidant capacity levels remained consistent and unchanged across both groups; however, superoxide dismutase activity was observed to be less active following chemical castration compared to surgical castration. Both surgical and chemical castration methods resulted in increased oxidative levels in male dogs, with the chemical process demonstrating a more pronounced effect by elevating malondialdehyde levels and diminishing antioxidant capacity. In summary, although total antioxidant capacity, superoxide dismutase, and malondialdehyde levels differ significantly between castrated and non-castrated dogs in both surgical and chemical methods, chemical castration imposes less oxidative stress on dogs than surgical methods. The results of this study have significant implications for post-castration care and treatment in dogs, as well as for the selection of castration methods. This may include the administration of antioxidants to mitigate the increase of free radicals. | ||
| کلیدواژه‌ها | ||
| Castration؛ Dogs؛ Oxidative Stress؛ Zinc Gluconate | ||
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آمار تعداد مشاهده مقاله: 7 تعداد دریافت فایل اصل مقاله: 15 |
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