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Forouhar Majd, Kianoush, Fatahian Dehkordi, Rahmat Allah, Nekooie Shahraki, Sajjad, Borzouei, Ahmadreza. (1404). Histomorphometric Evaluation of Renal Tissue in Alloxan-Induced Diabetic Male Wistar Rats: Protective Effects of Cinnamon Following Lead Acetate Toxicity. , (), 1-9. doi: 10.22103/vcbr.2025.25230.1069
Kianoush Forouhar Majd; Rahmat Allah Fatahian Dehkordi; Sajjad Nekooie Shahraki; Ahmadreza Borzouei. "Histomorphometric Evaluation of Renal Tissue in Alloxan-Induced Diabetic Male Wistar Rats: Protective Effects of Cinnamon Following Lead Acetate Toxicity". , , , 1404, 1-9. doi: 10.22103/vcbr.2025.25230.1069
Forouhar Majd, Kianoush, Fatahian Dehkordi, Rahmat Allah, Nekooie Shahraki, Sajjad, Borzouei, Ahmadreza. (1404). 'Histomorphometric Evaluation of Renal Tissue in Alloxan-Induced Diabetic Male Wistar Rats: Protective Effects of Cinnamon Following Lead Acetate Toxicity', , (), pp. 1-9. doi: 10.22103/vcbr.2025.25230.1069
Forouhar Majd, Kianoush, Fatahian Dehkordi, Rahmat Allah, Nekooie Shahraki, Sajjad, Borzouei, Ahmadreza. Histomorphometric Evaluation of Renal Tissue in Alloxan-Induced Diabetic Male Wistar Rats: Protective Effects of Cinnamon Following Lead Acetate Toxicity. , 1404; (): 1-9. doi: 10.22103/vcbr.2025.25230.1069

Histomorphometric Evaluation of Renal Tissue in Alloxan-Induced Diabetic Male Wistar Rats: Protective Effects of Cinnamon Following Lead Acetate Toxicity

Veterinary and Comparative Biomedical Research
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 24 مرداد 1404    اصل مقاله (924.56 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22103/vcbr.2025.25230.1069
نویسندگان
Kianoush Forouhar Majd1؛ Rahmat Allah Fatahian Dehkordi* 1؛ Sajjad Nekooie Shahraki1؛ Ahmadreza Borzouei2
1Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
2Department of Microbiology, Faculty of Basic Sciences, Shahroud Branch, Islamic Azad University, Shahroud, Iran
چکیده
Diabetes, a prevalent metabolic disorder, can lead to irreversible complications if not treated promptly. In animal models, diabetes is commonly induced using alloxan or streptozotocin. Lead initially accumulates in soft tissues such as the liver, kidneys, and spleen before depositing in hard tissues like bones, teeth, and hair. Various therapeutic approaches are employed to manage or treat diabetes. Cinnamon, containing compounds such as cinnamaldehyde (55–76%), eugenol (5–18%), safrole (less than 2%), and other constituents, exhibits remarkable antioxidant properties. This study utilized 24 male Wistar rats (200 ± 20 g) acclimatized for one week under a 12-hour light/dark cycle at 20 ± 2°C, inducing diabetes with 220 mg/kg alloxan, treating with 200 ppm lead acetate and 70 mg/kg/day cinnamon via oral gavage for 20 days, followed by tissue processing with 10% formalin fixation, paraffin embedding, Hematoxylin-Eosin staining, and data analysis using SPSS with ANOVA and Tukey’s test (p < 0.05). This study evaluated the histomorphometric effects of cinnamon on kidney tissue in diabetic rats compared to diabetic rats treated with lead acetate. Cinnamon (70 mg/kg) significantly reduced proximal tubule diameter (p < 0.05), restoring it to near control levels (6 µm), unlike the increased diameters in diabetic (7.5 µm) and lead acetate-treated (7 µm) groups. Cinnamon mitigated histological damage, suggesting antioxidant and anti-inflammatory protective effects against diabetes-induced renal alterations. Following cinnamon treatment, a decrease in the diameter of renal corpuscles, glomerular capillaries, and proximal and distal tubules was observed, accompanied by an increase in the thickness of Bowman's capsule space. 
کلیدواژه‌ها
Diabetes؛ Lead Acetate Toxicity؛ Renal Histomorphometry؛ Cinnamon؛ Rat
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