دانشگاه شهید باهنر کرمان

 آمار

تعداد نشریات26
تعداد شماره‌ها447
تعداد مقالات4,557
تعداد مشاهده مقاله5,380,003
تعداد دریافت فایل اصل مقاله3,580,074
Dashab, G. R.. (1394). Comparison of two QTL mapping approaches based on Bayesian inference using high-dense SNPs markers. , 3(1), 56-59. doi: 10.22103/jlst.2015.983
G. R. Dashab. "Comparison of two QTL mapping approaches based on Bayesian inference using high-dense SNPs markers". , 3, 1, 1394, 56-59. doi: 10.22103/jlst.2015.983
Dashab, G. R.. (1394). 'Comparison of two QTL mapping approaches based on Bayesian inference using high-dense SNPs markers', , 3(1), pp. 56-59. doi: 10.22103/jlst.2015.983
Dashab, G. R.. Comparison of two QTL mapping approaches based on Bayesian inference using high-dense SNPs markers. , 1394; 3(1): 56-59. doi: 10.22103/jlst.2015.983

Comparison of two QTL mapping approaches based on Bayesian inference using high-dense SNPs markers

Journal of Livestock Science and Technologies
مقاله 8، دوره 3، شماره 1، شهریور 2015، صفحه 56-59    اصل مقاله (452.76 K)
نوع مقاله: Research Article (Regular Paper)
شناسه دیجیتال (DOI): 10.22103/jlst.2015.983
نویسنده
G. R. Dashab*
Department of Animal Science, Faculty of Agriculture, University of Zabol
چکیده
To compare different QTL mapping methods, a population with genotypic and phenotypic data was simulated. In Bayesian approach, all information of markers can be used along with combination of distributions of SNP markers. It is assumed that most of the markers (95%) have minor effects and a few numbers of markers (5%) exert major effects. The simulated population included a basic population of 1020 non-relative cattle that was continuously crossed for 4 generations to make disequilibrium linkage among QTL position and markers. In all generations, 20 bulls were mated with 1,000 cows and each cow produced only one offspring. Whole tree family included 4100 head of livestock. Genotype of 10000 SNPs on 5 chromosomes at equal distance (0.05 cM) in the total population was simulated. The length of each chromosome was 100 cM. Simulated trait was milk production. Progeny of the first to third generation had record but the basic population and fourth generation of offspring did not have any record. Therefore, from the total population of 4100 heads, 3000 cattle had record. Two different models, Bayz A and Bayz B, were used to analyze QTL linked to the SNP markers. Analysis was conducted by BAYZ software. SNPs with more than 0.6 effect or Bayes factor (BF) greater than 5.5 were considered as QTL. The resultant analysis of two models of BAYZ A and BAYZ B were 7 and 9 QTL locations on 5 chromosomes, respectively. QTL position identified by BAYZ B method was matched on simulated location, but showed a false positive on chromosome 4. QTL positions identified by BAYZ A method were located near by the simulated positions, but with many false positive points.
کلیدواژه‌ها
bayesian analysis؛ QTL mapping؛ bayes factor؛ genomics
آمار
تعداد مشاهده مقاله: 1,948
تعداد دریافت فایل اصل مقاله: 1,042


سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب