دانشگاه شهید باهنر کرمان

 آمار

تعداد نشریات27
تعداد شماره‌ها485
تعداد مقالات5,091
تعداد مشاهده مقاله6,495,682
تعداد دریافت فایل اصل مقاله4,283,270
Kaboutari, Jahangir, Fatahian Dehkordi, Rahmat Allah, Amirkhani, Mehdi, Khosraviyan, Pegah. (1404). The Effects of the Curcumin-Loaded Selenium Nanoparticles on Hepatic Stereo-Histology, Blood Glucose, and Lipid Profile in Rats. , 2(1), 1-9. doi: 10.22103/vcbr.2024.24246.1027
Jahangir Kaboutari; Rahmat Allah Fatahian Dehkordi; Mehdi Amirkhani; Pegah Khosraviyan. "The Effects of the Curcumin-Loaded Selenium Nanoparticles on Hepatic Stereo-Histology, Blood Glucose, and Lipid Profile in Rats". , 2, 1, 1404, 1-9. doi: 10.22103/vcbr.2024.24246.1027
Kaboutari, Jahangir, Fatahian Dehkordi, Rahmat Allah, Amirkhani, Mehdi, Khosraviyan, Pegah. (1404). 'The Effects of the Curcumin-Loaded Selenium Nanoparticles on Hepatic Stereo-Histology, Blood Glucose, and Lipid Profile in Rats', , 2(1), pp. 1-9. doi: 10.22103/vcbr.2024.24246.1027
Kaboutari, Jahangir, Fatahian Dehkordi, Rahmat Allah, Amirkhani, Mehdi, Khosraviyan, Pegah. The Effects of the Curcumin-Loaded Selenium Nanoparticles on Hepatic Stereo-Histology, Blood Glucose, and Lipid Profile in Rats. , 1404; 2(1): 1-9. doi: 10.22103/vcbr.2024.24246.1027

The Effects of the Curcumin-Loaded Selenium Nanoparticles on Hepatic Stereo-Histology, Blood Glucose, and Lipid Profile in Rats

Veterinary and Comparative Biomedical Research
مقاله 1، دوره 2، شماره 1، شهریور 2025، صفحه 1-9    اصل مقاله (1.36 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22103/vcbr.2024.24246.1027
نویسندگان
Jahangir Kaboutari* 1؛ Rahmat Allah Fatahian Dehkordi1؛ Mehdi Amirkhani1؛ Pegah Khosraviyan2
1Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
2Medicinal Plant Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
چکیده
The application of novel pharmaceutical formulations of natural compounds, including those incorporating nanoparticles, represents a promising avenue for therapeutic advancement. The objective of this study was to examine the impact of curcumin-loaded selenium nanoparticles on the hepatic histological structure, as well as on blood glucose and lipids in rats. A total of 75 adult male rats were randomly assigned to one control group and four treatment groups. The control group was administered no medication, while the four treatment groups received the following: 50 mg/kg of curcumin (Group 1), 3.5 mg/kg of selenium nanoparticles (Group 2), combination of 50 mg/kg of curcumin plus 3.5 mg/kg of curcumin-loaded selenium nanoparticles (Group 3), and 5% DMSO (Group 4). On days 3, 7, and 14, blood samples were collected for biochemical testing and liver tissue samples were obtained. The hepatic tissue structure of the control, curcumin, and solvent groups exhibited no significant differences on days 3, 7, and 14. It was observed that the selenium nanoparticles group exhibited notable alterations in tissue structure, which were markedly diminished in the curcumin-loaded selenium nanoparticles group. Notable stereological findings were observed in the selenium nanoparticles group in comparison to the control group, including an increase in the volume density of hepatocytes and sinusoids, accompanied by a reduction in the volume density of central veins. No significant alterations were observed in the triglyceride and cholesterol levels in the experimental groups. It can be concluded that the administration of curcumin-loaded selenium nanoparticles to rats demonstrated notable hepatoprotective effects against selenium nanoparticles.
کلیدواژه‌ها
Curcumin؛ Histomorphometry؛ Selenium nanoparticles؛ Stereology
مراجع
  1. Baum L, Ng A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. Journal of Alzheimer's disease. 2004;6(4):367-77.
  2. Hsieh C. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21(2895):e2900.
  3. Kaboutari J, Ghorbani M, Karimibabaahmadi B, Javdani M, Khosraviyan P. Anti-inflammatory evaluation of the novel slow-release curcumin-loaded selenium nanoparticles in the experimental peritonitis. Iranian Journal of Veterinary Medicine. 2023.
  4. Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical reviews in food science and nutrition. 2017;57(13):2889-95.
  5. Hosack T, Damry D, Biswas S. Drug-induced liver injury: a comprehensive review. Therapeutic Advances in Gastroenterology. 2023;16:17562848231163410.
  6. Amiri A, Dehkordi RAF, Heidarnejad MS, Dehkordi MJ. Effect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study. Biological trace element research. 2018;181:258-64.
  7. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16(2):109-10.
  8. Hornstein B, Stammler L, Bianchi L, Landmann L. Ethinylestradiol increases volume and decreases sinusoidal membrane surface in the rat liver: a stereological analysis. Hepatology. 1992;16(1):217-23.
  9. Jia X, Li N, Chen J. A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats. Life sciences. 2005;76(17):1989-2003.
  10. Hajinezhad MR, Jamshidian A, Abdollahi M, Kermani AS. Comparing the Histopathological Effects of Selenium Nanoparticles and Selenium Nanocomposites in Rat Models. Disease and Diagnosis. 2021;10(2):75-81.
  11. He Y, Chen S, Liu Z, Cheng C, Li H, Wang M. Toxicity of selenium nanoparticles in male Sprague–Dawley rats at supranutritional and nonlethal levels. Life sciences. 2014;115(1-2):44-51.
  12. Aghaei B. Evaluation of the effects ofcurcumin on palm inflammation and level of acute phase proteins in arthritic rats. 2008.
  13. Lee DE, Lee SJ, Kim SJ, Lee H-S, Kwon O-S. Curcumin ameliorates nonalcoholic fatty liver disease through inhibition of O-GlcNAcylation. Nutrients. 2019;11(11):2702.
  14. Zaafan MA, Zaki HF, El-Brairy AI, Kenawy SA. Pyrrolidinedithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parameters. Experimental Lung Research. 2016;42(8-10):408-16.
  15. Agarwal H, Nakara A, Shanmugam VK. Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review. Biomedicine & Pharmacotherapy. 2019;109:2561-72.
  16. Khurana A, Tekula S, Saifi MA, Venkatesh P, Godugu C. Therapeutic applications of selenium nanoparticles. Biomedicine & Pharmacotherapy. 2019;111:802-12.
  17. Shahabi R, Anissian A, Javadmoosavi SA, Nasirinezhad F. Protective and anti-inflammatory effect of selenium nano-particles against bleomycin-induced pulmonary injury in male rats. Drug and Chemical Toxicology. 2021;44(1):92-100.
  18. Sunoqrot S, Abu Shalhoob M, Jarrar Y, Hammad AM, Al-Ameer HJ, Al-Awaida W. Nanoencapsulated Curcumin Mitigates Liver Injury and Drug-Metabolizing Enzymes Induction in Diclofenac-Treated Mice. ACS omega. 2024;9(7):7881-90.
  19. Siasos G, Tousoulis D, Tsigkou V, Kokkou E, Oikonomou E, Vavuranakis M, et al. Flavonoids in atherosclerosis: an overview of their mechanisms of action. Current medicinal chemistry. 2013;20(21):2641-60.
  20. Ferguson JJ, Stojanovski E, MacDonald-Wicks L, Garg ML. Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial. Metabolism. 2018;82:22-35.
  21. Shin SK, Ha TY, McGregor RA, Choi MS. Long‐term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Molecular nutrition & food research. 2011;55(12):1829-40.
  22. Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M, et al. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial. Nutrition & metabolism. 2019;16:1-13.
  23. Ansari JA, Malik JA, Ahmed S, Manzoor M, Ahemad N, Anwar S. Recent advances in the therapeutic applications of selenium nanoparticles. Molecular Biology Reports. 2024;51(1):688.
  24. Liu Z, Cui C, Xu P, Dang R, Cai H, Liao D, et al. Curcumin activates AMPK pathway and regulates lipid metabolism in rats following prolonged clozapine exposure. Frontiers in neuroscience. 2017;11:558.
  25. Guo L, Xiao J, Liu H, Liu H. Selenium nanoparticles alleviate hyperlipidemia and vascular injury in ApoE-deficient mice by regulating cholesterol metabolism and reducing oxidative stress. Metallomics. 2020;12(2):204-17.
  26. Atoum MF, Padma KR, Don KR. Curcumin is a potential therapeutic agent that ameliorates diabetes among non-alcoholic fatty liver disease coexist with type 2 diabetes. Nutrition and Healthy Aging. 2024;9(1):77-90.
  27. Abdulmalek S, Eldala A, Awad D, Balbaa M. Ameliorative effect of curcumin and zinc oxide nanoparticles on multiple mechanisms in obese rats with induced type 2 diabetes. Scientific reports. 2021;11(1):20677.
  28. Na L-X, Zhang Y-L, Li Y, Liu L-Y, Li R, Kong T, et al. Curcumin improves insulin resistance in skeletal muscle of rats. Nutrition, Metabolism and Cardiovascular Diseases. 2011;21(7):526-33.
  29. Balakumar P, Venkatesan K, Khan NA, Raghavendra N, Venugopal V, Bharathi D, et al. Mechanistic insights into the beneficial effects of curcumin on insulin resistance: opportunities and challenges. Drug Discovery Today. 2023;28(7):103627.
آمار
تعداد مشاهده مقاله: 224
تعداد دریافت فایل اصل مقاله: 263


سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب